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In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death.
In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community. |
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Applications in Engineering, Life and Social Sciences (De Gruyter Reference)
Fractional Calculus (FC) has originated in 1695, nearly at the same time as conventional calculus. However, FC attracted limited attention and remained a pure mathematical exercise in spite of the original contributions of important mathematicians,
physicists and engineers. FC had a rapid development during the last few decades,
both in... | | | | Pro SharePoint 2010 Development for Office 365
Welcome to the world of customization and development for SharePoint Online in Office 365. Although
Office 365 offers lots of opportunities for businesses and developers, it also represents a different
development and deployment paradigm from what most SharePoint developers are accustomed to in a
traditional on-premise environment.... |
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