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DNA Topoisomerases and Cancer (Cancer Drug Discovery and Development)

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DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

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The Proceedings of the Second International Conference on Communications, Signal Processing, and Systems
The Proceedings of the Second International Conference on Communications, Signal Processing, and Systems

The Proceedings of The Second International Conference on Communications, Signal Processing, and Systems provides the state-of-art developments of Communications, Signal Processing, and Systems. The conference covered such topics as wireless communications, networks, systems, signal processing for communications. This book is a collection of...

Software Engineering for Absolute Beginners: Your Guide to Creating Software Products
Software Engineering for Absolute Beginners: Your Guide to Creating Software Products

Start programming from scratch, no experience required. This beginners’ guide to software engineering starts with a discussion of the different editors used to create software and covers setting up a Docker environment. Next, you will learn about repositories and version control along with its uses. Now that you are ready to...

Computing Information Technology: The Human Side
Computing Information Technology: The Human Side
From the senior management to the clerical and support group levels, this study addresses the possible pitfalls and triumphs of implementing information technology (IT) into organizations in terms of organizational strategies, structures, and communication methods. Issues of human-computer interaction, ethics, privacy, and security are raised to...

Sams Teach Yourself Visual C# 2008 in 24 Hours: Complete Starter Kit
Sams Teach Yourself Visual C# 2008 in 24 Hours: Complete Starter Kit
In just 24 sessions of one hour or less, you will be up and running with Visual C# 2008. Using a straightforward, step-by-step approach, each lesson builds upon the previous one, allowing you to learn the essentials of Visual C# from the ground up.

 

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Ins and Outs of prepositions, The : A Guidebook for ESL Students
Ins and Outs of prepositions, The : A Guidebook for ESL Students
Though written primarily for students of English as a Second Language, The Ins and Outs of Prepositions is also useful in remedial English courses on high school and college freshman levels. Unlike most languages - which usually have only a few prepositions to serve many different communication needs- English has dozen of them and almost none...
Using Microsoft Windows Small Business Server 2003
Using Microsoft Windows Small Business Server 2003
This is the fundamental, definitive reference to Microsoft Small Business Server 2003. And it is relevant for all audiences: for beginners just embracing the notion of computerizing their small businesses, to IT consultants specializing in SBS implementation and deployment.

The book focuses on pragmatic solutions, not drawn-out theoretical...

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