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Malaria: Genetic and Evolutionary Aspects (Emerging Infectious Diseases of the 21st Century)

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This book is an edited collection of papers by leading experts on the population genetics and evolutionary biology of malaria, a disease which results in three million deaths each year in the world. "Malaria Hypothesis" refers to the hypothesis, which was proposed by J.B.S. Haldane at the 8th International Congress of Genetics in Stockholm in 1948, that the identical geographic distribution of both falciparum malaria and thalassemia in the mediterranean region suggests that the heterozygous individuals for thalassemia (or microcythemia as it was called then) might have greater resistance to malarial infection. Haldane, later in the same year, expanded his theory to infectious disease in general at another international conference, at Pallanza in Italy. Haldane's hypothesis was subsequently confirmed in the African populations by A.C. Allison and later by others during the last fifty years, although at first for sickle cell anemia and later for thalassemia with varying degrees of success. The malaria hypothesis still remains today a unique example of that kind of balanced polymorphism, not only in genetics but in all of biology. It opened up new insights into our perspective of the genetics and population dynamics of disease prevalence, particularly infectious disease.

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ISA System Architecture (3rd Edition)
ISA System Architecture (3rd Edition)

*ISA System Architecture describes the hardware architecture of ISA (Industry Standard Architecture), providing a clear, concise explanation of an ISA system in detail. The authors provide a comprehensive treatment of the bus including: **-bus cycles *-addressing *-I/O *-RAM, ROM, and cache memory *-cache architectures *-decode and reset...

Electronic Structure and Magneto-Optical Properties of Solids
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The aim of this book is to review recent achievements in the theoretical investigations of the electronic structure, optical, magneto-optical (MO), and x-ray magnetic circular dichroism (XMCD) properties of compounds and Multilayered structures.

Chapter 1 of this book is of an introductory character and presents the theoretical
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Pairing-Based Cryptography - Pairing 2010: 4th International Conference
Pairing-Based Cryptography - Pairing 2010: 4th International Conference

This book constitutes the refereed proceedings of the 4th International Conference on Pairing-Based Cryptography, Pairing 2010, held in Yamanaka Hot Spring, Japan, in December 2010. The 25 full papers presented were carefully reviewed and selected from 64 submissions. The contributions are organized in topical sections on: efficient software...


Advances in Mathematical Modeling for Reliability
Advances in Mathematical Modeling for Reliability
Advances in Mathematical Modeling for Reliability discusses fundamental issues on mathematical modeling in reliability theory and its applications. Beginning with an extensive discussion of graphical modeling and Bayesian networks, the focus shifts towards repairable systems: a discussion about how sensitive availability calculations parameter...
Trust and Legitimacy in Criminal Justice: European Perspectives
Trust and Legitimacy in Criminal Justice: European Perspectives

The book explores police legitimacy and crime control, with a focus on the European region. Using comparative case studies, the contributions to this timely volume examine the effects of a transition to democracy on policing, public attitudes towards police legitimacy, and the ways in which perceptions of police legitimacy relate to...

The Tipping Point: How Little Things Can Make a Big Difference
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The Tipping Point is that magical moment when an idea, trend, or social behaviour crosses a threshhold, tips, and spreads like wildfire. Just as a sick individual in a crowded store can start can epidemic of the flu, so too can a small but precisely targeted push cause a fashion trend or the popularity of a new restaurant to take off overnightor...
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