​This dedicated volume in the series Advances and Technical Standards in Neurosurgery (ATSN) provides a comprehensive approach to diseases of the craniovertebral junction (CVJ) and their management based on the multidisciplinary cooperation of neurosurgeons, anatomists, neuroradiologists, and neuroanesthesiologists. The contributing authors represent the most renowned clinical and surgical experts from Europe and beyond. The main topics highlighted are embryology, normal and abnormal development of the CVJ, including the related vessels, modern radiological contributions to diagnosis, genetic and metabolic factors which may impact on the surgical strategies, the opportunities offered by traditional operative techniques, and the recently introduced minimally invasive and endoscopic surgical modalities. Special emphasis is also placed on the evolution of the principles of surgical treatment as matured during the past decade by experiences in the still open field of pediatric neurosurgery.