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TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs).
This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade.
The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.
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 Hacking the Cable Modem: What Cable Companies Don't Want You to KnowIn the beginning there was dial-up, and it was slow; then came broadband in the form of cable, which redefined how we access the internet, share information, and communicate with each other online. Hacking the Cable Modem goes inside the device that makes Internet via cable possible and, along the way, reveals secrets of many popular cable... | | Matrix Analysis for Scientists and Engineers‘I found Laub's book a delightful read. It has become the sixth valuable ‘Matrix Analysis’ book on my shelves. As well as being admirably suited for the course at which it is aimed, its conciseness and clarity of presentation, together with the good index, make it easy to use for reference. The book is recommended both as a course... | | Handbook of Global Logistics: Transportation in International Supply Chains
Global logistics entails tradeoffs in facility location, distribution networks, the routing and scheduling of deliveries by different modes of travel (e.g., air, water, truck, rail), procurement, and the overall management of international supply chains. In an increasingly global economy, then, logistics has become a very important matter in... |
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