A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening,...

Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric,...

A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional...

Leading world authorities drawn from cardiology, surgery, pediatrics, internal medicine, and basic science comprehensively survey the diagnostic, therapeutic, and prognostic aspects of cardiogenic shock. These experts describe the different scenarios leading to cardiogenic shock, the ways to diagnose their causes, the unique therapeutic...

A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation,...

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and...

Leading experts in the fields of gastroenterology, surgery, and radiology comprehensively review the pathophysiology, diagnosis, management, and treatment of acute bleeding disorders of the GI tract. The authors break down acute bleeding into upper and lower GI tract sources and provide a differential diagnosis for each disease,...

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division...

Trauma and exposure to toxic and infectious agents invariably lead to organ damage followed by significant morbidity and mortality. Although these conditions have typically been associated with the battlefield, today they are more prevalent in urban areas. The events of September 11,2001 have brought this problem to the forefront of national...

Richard A. Prayson, md, summarizes in outline form for active pathologists and residents in training-as well as those seeking a concise up-to-date overview of the subject -the essential element of the neuropathology curriculum. Topics range from basic information on the spectrum of neurologic-related disease to pertinent pictorial examples of...

Through the rapid development of proteomics methods and technologies, an enormous amount of data was created, leading to a wide-spread rethinking of strategy design and data interpretation. In Data Mining in Proteomics: From Standards to Applications, experts in the field present these new insights within the proteomics community, taking the...