Dietary restriction uniquely and robustly increases maximum lifespan and greatly reduces age-related diseases in many species, including yeast, flies, nematodes, and mammals. To study mechanisms mediating the protective effects of dietary restriction, the National Institute of Aging convened a program involving several leading gerontological...
It is well-known that the daily diet plays an important role in the preservation and integrity of renal function in patients with chronic kidney disease. However, there currently exists some confusion as to the right diet because of the MDRD (Modification of Diet in Renal Disease) study, which has shown that a low-protein diet does not have a...
Dental Erosion: A challenge for the 21st century! This monograph offers a
guide towards better oral health in the future. Erosive tooth wear is a multifactorial
condition of growing concern to the clinician and the subject of extensive
research – a view supported by the literature and impressions from many international...
In 1999, my colleagues and I performed a study in 7
hospitals in different regions throughout Spain where 305
patients were questioned about their use of antimigraine
medications [1] . The patients reported previous use of the
following acute agents: analgesics (99%), nonsteroidal antiinfl
ammatory drugs (NSAIDs, 69%),...
Over the next decade, the global number of people with diabetes and at risk of diabetes and cardiovascular disease is expected to grow by 25%, largely driven by the rising prevalence of obesity and inactivity. The problem is especially serious in Asia, where the WHO predicts that in less than a decade, 60% of the worldwide population with...
This is the only comprehensive collection of algorithms which exclusively addresses hematologic and oncologic problems affecting neonates, children and adolescents. Examining clinical problems which challenge the pediatrician, general practitioner and family practice physician, each algorithm utilizes a concise, step-by-step approach based...
A Karger 'Publishing Highlights 1890–2015' title
Over the past years, research into the Prader-Willi syndrome (PWS) and its treatment options has progressed enormously and new insights have greatly improved the quality of life of those affected. For many years, Urs Eiholzer has been engaged in the care of...
Epidemiology of Pediatric Sport Injuries reviews integratively the existing data on distribution and determinants of injury rates in a variety of sports, and suggests injury prevention measures and guidelines for further research. This volume focuses on individual sports, as the next volume will discuss team sports. Together the two volumes...
Is the risk of injury greater in some sport activities than in others? What types of injuries are most common? Are some children prone to sports injury? Are some physical, psychological, or sport-related factors associated with an increased risk of injury? Can injury be prevented and if so, how? Epidemiology of Pediatric Sport Injuries...
This book unfolds the history of the discovery of the transmembrane channel which is responsible for the ‘funny’ or If current, the primary modulator of heart rate. Inhibition of this current leads to slowing of the heart rate, which is an important component of the successful management of angina pectoris....
Significant advances in the treatment of patients with
cancer have occurred over the last decade, as evidenced
by steadily improving cure rates and extended durations
of survival. There is often a critical trade-off, however,
because more intense cytotoxic regimens may result in
increased adverse events, including an...
