A panel of leading researchers and clinician-scientists distill from years of practical experience and recent scientific and clinical advances the essence of cardiology principles and techniques today. In this second edition, all of the original chapters have been extensively rewritten and two new chapters on acute coronary syndromes...

In this second edition of his highly acclaimed book, Christopher P. Cannon, MD, and a team of preeminent clinical investigators have thoroughly revised and expanded every chapter to reflect the recent explosion of clinical trials on the management of acute coronary syndromes (ACS). This includes: the newer tests, such as C reactive protein; a...

During the past few decades, technical and conceptual breakthroughs have led to a virtual revolution in developmental biology. In part through cross-species compa- sons and multidisciplinary approaches (combining, for example, classical embry- ogy, genetics, molecular biology, and systems biology), major questions have often been redefined...

Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to...

This collection of readily reproducible molecular techniques and related in vitro/in vivo model systems can be used to explore the causes of autoimmunity, as well as how best it may be regulated. There are methods to assess immunological and biochemical pathways relevant for pathogenesis and to establish and assess a variety of autoimmune...

A comprehensive assessment of the clinical, psychological, legal, and cultural aspects of dealing with unnecessary pain in the elderly. The authors explore pharmacotherapy (nonopioids, opioids, and adjuvants), interventional strategies, the role of rehabilitation in managing pain in seniors, and the problems of pain management in long-term...

This distinguished reference carries on a 70-year legacy as the world's most thorough, useful, readable, and understandable text on the principles and techniques of surgery. Its peerless contributors deliver all the well-rounded, state-of-the-art knowledge you need to richly grasp the pathophysiology and optimal management of every...

Primary care physicians must be prepared to face urgent and emergent patient complaints and presentations in the office. How do you prepare your office for an emergency? What conditions can and should be treated in the office without the need to transport the patient? What entities require urgent/emergent transfer to the Emergency Department?...

A source of stability and mobility, the hip can withstand a lot of abuse before becoming seriously damaged. When injury occurs no one is happy and movement is often stressful. Fixing and repairing the injured hip is covered in this issue. Chapters in this issue cover hip fractures, stress fractures, instability, impingement, rehabilitation,...