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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 1

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The aim of Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms is to present recent developments in cell survival and apoptotic pathways and their involvement in human diseases, such as cancers and neurodegenerative disorders. This requires an integration of knowledge from several fields of research, including pathology, genetics, virology, cell biology, medicine, immunology, and molecular biology. This edition of the book examines the impact of molecular biology on disease mechanisms. With recent advances in technology such as microarray and proteomics, new biomarkers and molecular targets have been identified. These potential targets will be very useful for the development of novel and more effective drugs for the treatment of human diseases. The challenge now is not only to understand disease mechanisms but also to apply this knowledge to find therapies that are more effective.

Cellular processes play major roles in cell survival and apoptosis. These events are essential for tissue homeostasis and the maintenance of proper growth and development of multicellular organisms. Imbalance in survival and apoptotic pathways may lead to several diseases. Therefore, understanding the molecular mechanisms of cell survival and apoptotic pathways is essential for the treatment and prevention of human diseases. The main focus of Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms is to discuss the recent development in cell signaling events, growth, metastasis, and angiogenesis, mechanisms of drug resistance, and targeted therapy for human diseases. Volume 1 contains 15 chapters divided into two sections: “Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy”; Volume 2 contains 18 chapters, also divided into two sections: “Kinases and Phosphatases” and “Molecular Basis of Cell Death.” Scientists well known in their fields have contributed to this book.
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