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Cancer Drug Resistance (Cancer Drug Discovery and Development)

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Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

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Neural and Fuzzy Logic Control of Drives and Power Systems
Neural and Fuzzy Logic Control of Drives and Power Systems
The idea of writing this book arose from the need to investigate the main principles of modern power electronic control strategies, using fuzzy logic and neural networks, for research and teaching. Primarily, the book aims to be a quick learning guide for postgraduate/undergraduate students or design engineers interested in...
Mastering Prezi for Business Presentations
Mastering Prezi for Business Presentations
If you've discovered Prezi in the last few years or even very recently, you have joined part of an interesting movement that's rapidly changing how ideas are shared. If you're reading this now then there's no doubt in our minds you're completely sold on the fact that business presentations need to change....
What White Boyz Desire
What White Boyz Desire

What White Boyz Desire Purr-fect Kitty by Kelley Nyrae With the help of a match-making cat, writer, Jasmine Briers learns that just as you shouldn’t judge a book by its cover, she shouldn’t judge a man by what she witnesses peeking through her window. And she just might find her puuurfect match. Invisible Love By Alexis Ke Alana...


An Introduction to Optimization, 2nd Edition
An Introduction to Optimization, 2nd Edition
A modern, up-to-date introduction to optimization theory and methods
This authoritative book serves as an introductory text to optimization at the senior undergraduate and beginning graduate levels. With consistently accessible and elementary treatment of all topics, An Introduction to Optimization, Second Edition helps students build a
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Cambridge Handbook of Strategy as Practice
Cambridge Handbook of Strategy as Practice

The Cambridge Handbook of Strategy as Practice provides the first comprehensive overview of an emerging and growing stream of research in strategic management. An international team of scholars has been assembled to produce a systematic introduction to the various epistemological, methodological and theoretical aspects of the...

Mathematics of Discrete Structures for Computer Science
Mathematics of Discrete Structures for Computer Science

Mathematics plays a key role in computer science, some researchers would consider computers as nothing but the physical embodiment of mathematical systems. And whether you are designing a digital circuit, a computer program or a new programming language, you need mathematics to be able to reason about the design -- its correctness,...

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