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Cardiac Gene Expression: Methods and Protocols (Methods in Molecular Biology)

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This book presents both cutting-edge and established methods for studying cardiac gene expression. The protocols provide a template for solid research, and cover the process through screening, analysis, characterization, and functional confirmation of novel genes or known genes with a new function. The concluding section of the book highlights methods that facilitate overexpression or cardiac-specific targeted gene deletion.

The past decade has ushered in enormous changes in how we perceive and study changes in gene expression in the heart. Early in the 1990s, the human genome project was just getting underway and establishing methods with the sensitivity to measure changes in the expression of genes with low copy number was an accomplishment. We all experienced some trepidation when the first news of microarrays arrived espousing the ability to measure changes in expression of hundreds to tens of thousands of genes (the whole genome) at once. This high throughput method was an astonishing jump in our approach to biological science. At the same time Steve Fodor and Pat Brown published papers describing two completely different approaches to measuring the expression changes of large numbers of genes at the same time. Thus began the microarray era and as a consequence the beginning of an era with a host of new approaches in pursuit of understanding the role and regulation of gene expression in cell biology and pathology including driving forward the field of bioinformatics.

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Isosurfaces: Geometry, Topology, and Algorithms
Isosurfaces: Geometry, Topology, and Algorithms

Ever since Lorensen and Cline published their paper on the Marching Cubes algorithm, isosurfaces have been a standard technique for the visualization of 3D volumetric data. Yet there is no book exclusively devoted to isosurfaces. Isosurfaces: Geometry, Topology, and Algorithms represents the first book to focus on basic...

Lactic Acid Bacteria: Biodiversity and Taxonomy
Lactic Acid Bacteria: Biodiversity and Taxonomy

The lactic acid bacteria (LAB) are a group of related micro-organisms that are enormously important in the food and beverage industries, preventing food spoilage and extending shelf life. This is the first reference that provides a much-needed and comprehensive account of the current knowledge of LAB, detailing the taxonomy, biochemistry,...

A Mathematical Introduction to Fluid Mechanics (Texts in Applied Mathematics) (v. 4)
A Mathematical Introduction to Fluid Mechanics (Texts in Applied Mathematics) (v. 4)

The goal of this text is to present some of the basic ideas of fluid mechanics in a mathematically attractive manner, to present the physical background and motivation for some constructions that have been used in recent mathematical and numerical work on the Navier-Stokes equations and on hyperbolic systems and to interest some of the...


Oracle Siebel CRM 8 Installation and Management
Oracle Siebel CRM 8 Installation and Management

Oracle's Siebel CRM is market-leading Customer Relationship Management software. Unmatched in functionality and scalability, Siebel enhances a company's sales performance, improves customer satisfaction, and provides a robust Customer Relationship Management system for an organization.

This practical book offers a...

Advanced SQL Functions in Oracle 10g
Advanced SQL Functions in Oracle 10g
Oracle® 10g has introduced new features into its repertoire of SQL instructions that make database queries more versatile. When programmers use SQL in Oracle, they inevitably look for easier and new ways to handle queries. What is needed is a way to introduce SQL users to the new features of Oracle 10g concisely and systematically so that...
Bad Data Handbook: Cleaning Up The Data So You Can Get Back To Work
Bad Data Handbook: Cleaning Up The Data So You Can Get Back To Work

What is bad data? Some people consider it a technical phenomenon, like missing values or malformed records, but bad data includes a lot more. In this handbook, data expert Q. Ethan McCallum has gathered 19 colleagues from every corner of the data arena to reveal how they’ve recovered from nasty data problems.

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