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Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important ‘caretaker’ genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume. This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease. |
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 Eclipse Rich Ajax Platform: Bringing Rich Client to the Web (FirstPress)
Eclipse Rich Ajax Platform (RAP) is an innovative toolkit for developing applications that will run as rich clients as well as web applications. Eclipse Rich Ajax Platform is the first book on the new Eclipse RAP, and it introduces the required RCP and OSG/i concepts used by Eclipse RAP.
This firstPress title demonstrates... | | JavaFX 1.2 Application Development Cookbook
JavaFX Script enables you to easily create rich Internet applications by embedding multimedia components. Although you can create stylish Internet applications by modifying these default components, even advanced users find it challenging to create impressive feature-rich Internet applications with JavaFX. Also, there are limited JavaFX... | | Get Rich Playing Games
GET PAID TO PLAY! 30 years in the making, the first book to offer everything you need to go from rags to riches in the fabulous videogame industry is here - are you ready to nail the ultimate high score? A must-have for anyone seeking a career in game art, design, audio, programming, marketing, journalism and sales! Learn how to break into... |
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