Multidimensional Liquid Chromatography: Theory and Applications in Industrial Chemistry and the Life Sciences

Multidimensional Liquid Chromatography: Theory and Applications in Industrial Chemistry and the Life Sciences, 9780471738473 (0471738476), John Wiley & Sons, 2008

At least two driving forces have contributed to the recent increased use and development of multidimensional liquid chromatography (MDLC). These include the high resolution and peak capacity needed for proteomics studies and the independent size and chemical structure selectivity for resolving industrial polymers. In this regard, separation science focuses on a system approach to separation as individual columns can contribute only part of the separation task and must be incorporated into a larger separation system for a more in-depth analytical scheme.

Separation techniques are increasingly used to resolve molecular structure at a finer and finer scale and in chemical environments that are fundamentally complex. This applies not only to small and medium-sized (<1000 Da) molecules but also to polymers, nanoparticles, and colloidal-sized chemical structures. Of particular importance is when a small change in molecular structure modifies a response or behavior of another molecule. This is often the case in the life sciences where resolution of biomarker molecules can be a key to early disease detection. The complexity of the biomarker problem is high as the biomarker molecule may be present as a minor- or trace-level component (very large dynamic range), and its structure may be a slight modification of something present in far larger concentration (large structural diversity).

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