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Yeast as a Tool in Cancer Research

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Yeast as a Tool in Cancer Research, 9781402059629 (1402059620), Springer, 2007

Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein–protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind’s most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.

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Intracranial Tumors: Diagnosis and Treatment
Intracranial Tumors: Diagnosis and Treatment

Brain tumors have a longstanding reputation for being intractable to therapy, and with evidence suggesting that the incidence of some brain tumors is increasing, this has become the most feared cancer. However, with improvements in imaging technologies, radiation therapy and chemotherapy , as well as a greater knowledge of the genetic causes...

The Power of Algorithms: Inspiration and Examples in Everyday Life
The Power of Algorithms: Inspiration and Examples in Everyday Life

To examine, analyze, and manipulate a problem to the point of designing an algorithm for solving it is an exercise of fundamental value in many fields. With so many everyday activities governed by algorithmic principles, the power, precision, reliability and speed of execution demanded by users have transformed the design and...

Grammar of the English Verb Phrase: Volume 1: The Grammar of the English Tense System (Topics in English Linguistics 60.1)
Grammar of the English Verb Phrase: Volume 1: The Grammar of the English Tense System (Topics in English Linguistics 60.1)
The Grammar of the English Tense System forms the first volume of a four-volume set, The Grammar of the English Verb Phrase. The other volumes, to appear over the next few years, will deal with mood and modality, aspect and voice.

The book aims to provide a grammar of tense which can be used both as an advanced reference grammar (for...


Mastering AutoCAD 2008 and AutoCAD LT 2008
Mastering AutoCAD 2008 and AutoCAD LT 2008
The World's Bestselling AutoCAD Resource Fully Updated for 2008

There's a reason why Mastering AutoCAD is so popular year after year. Loaded with concise explanations, step-by-step instructions, and hands-on projects, this comprehensive reference and tutorial from award-winning author George Omura has everything you...

Schaum's Outline of German Vocabulary, 3ed (Schaum's Outline Series)
Schaum's Outline of German Vocabulary, 3ed (Schaum's Outline Series)

Confusing Textbooks? Missed Lectures? Not Enough Time?

Fortunately for you, there's Schaum's Outlines. More than 40 million students have trusted Schaum's to help them succeed in the classroom and on exams. Schaum's is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course...

Hardware Design Verification : Simulation and Formal Method-Based Approaches
Hardware Design Verification : Simulation and Formal Method-Based Approaches

The Practical, Start-to-Finish Guide to Modern Digital Design Verification

As digital logic designs grow larger and more complex, functional verification has become the number one bottleneck in the design process. Reducing verification time is crucial to project success,...

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