Scientific medicine in Miettinen’s conception of it is very different from the two ideas about it that come to eminence in the 20^th century.  To him, medicine is scientific to the extent that it has a rational theoretical framework and a knowledge-base from medical science.  He delineates the nature of that...

The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all reaches of the human body. Today, clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary...

This book collects several contributions, written both by statisticians and medical doctors, which focus on the identification of new diagnostic, therapeutic and organizational strategies in order to improve the occurrence of clinical outcomes for Acute Coronary Syndromes (ACS) patients. The work is structured in two different...

This book provides clinicians with a broader understanding of screening and preventive diagnosis using radiological imaging. The first part of the book is dedicated to the fundamentals of screening and preventive diagnosis. The second part of the book discusses the most important practical examples of radiological screening and surveillance,...

IgG4-related disease is a new systemic disease that has only recently been identified and characterized. However, most clinical practitioners are not yet familiar with it and thus are likely to misdiagnose it. The purpose of this book is to raise awareness of this disease and its diagnostic pitfalls. A wealth of radiological and...

One of the most fruitful areas of research, as judged by the very large numbers of new cancer genes identified, has been the molecular analysis of recurrent chromosomal translocations. The original concept that gave rise to this book was that key scientists involved in the original isolation of the genes involved in each recurrent solid tumor...