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Diseases of the Liver & Biliary System

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The eleventh edition welcomes the new Millenium. Progress in basic and clinical hepatology remains exponential. Since 1997, the advances have been wideranging, with those in molecular and cellular biology, and in diagnosis and treatment, leading the way. In a world in which information technology gives all too ready access to individual publications, the eleventh edition sets the new within established knowledge and practice.

Viral hepatitis remains the worldwide hepatological challenge. This is reflected in a change in format with separate chapters on hepatitis B and C. Molecular virology continues to expose the inner workings of all the viruses. New therapeutic approaches are proving more effective against hepatitis C. Molecular and cellular biologists are showing us the importance of apoptosis and the intricate regulation of fibrosis. Mutation analysis for diagnosis of genetic haemochromatosis is routine, while the identification of the haemochromatosis gene has led to a surge of exploration in iron metabolism. Canalicular transporters have been cloned and linked to cholestatic syndromes, giving a new perspective to the bile plug seen under the microscope. Advances in imaging, particularly magnetic resonance, continue to reduce the need for invasive techniques. Patients needing transplantation benefit from improvements in immunosuppression and surgical techniques, while there is steady progress in the management of complications of cirrhosis.

This edition contains more than 1000 new references and 100 new figures. Developments in publishing allow a more colourful format, but care has been taken to preserve clarity. Experience has shown that students, interns, postgraduate trainees as well as generalists and specialist clinicians have found previous editions useful. The goal of the book remains unchanged: a textbook of manageable size, critical and current.
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