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Growth Factors and Their Receptors in Cancer Metastasis

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about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

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Zen Cart: E-commerce Application Development: A step-by-step developer's guide
Zen Cart: E-commerce Application Development: A step-by-step developer's guide

Zen Cart is a popular open-source PHP/MySQL-based e-commerce solution available under GPL that is designed to put the merchants' and shoppers' requirements first. Not only does Zen Cart offer a very long list of features, but the system is designed with both store owners and web developers in mind. There's no sacrifice of usability or power.

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Beginning JSP, JSF and Tomcat Web Development: From Novice to Professional
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Start building Java-based web applications now, even if you’re a complete newcomer to Java. Comprehensive and example-driven, Beginning JSP™, JSF™, and Tomcat Web Development is all you need to develop dynamic web applications using JSP, connect to databases with JSF, and put them into action using the world’s...

Biodegradable Polymer-Based Scaffolds for Bone Tissue Engineering (SpringerBriefs in Applied Sciences and Technology)
Biodegradable Polymer-Based Scaffolds for Bone Tissue Engineering (SpringerBriefs in Applied Sciences and Technology)

This book addresses the principles, methods and applications of biodegradable polymer based scaffolds for bone tissue engineering. The general principle of bone tissue engineering is reviewed and the traditional and novel scaffolding materials, their properties and scaffold fabrication techniques are explored. By acting as temporary synthetic...


Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms (Advances in Biochemistry in Health and Disease)
Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms (Advances in Biochemistry in Health and Disease)

Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to...

Cinema 4D R14 Cookbook, 2nd Edition
Cinema 4D R14 Cookbook, 2nd Edition

Elevate your art to the fourth dimension with Cinema 4D R14

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Communication Technology Update and Fundamentals, Twelfth Edition
Communication Technology Update and Fundamentals, Twelfth Edition

New communication technologies are being introduced at an astonishing rate. Making sense of these technologies is increasingly difficult. Communication Technology Update is the single best source for the latest developments, trends, and issues in communication technology. Now in its 12th edition, Communication Technology Update has become an...

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