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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics (Cancer Drug Discovery and Development)

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There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer.

Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs.

  • Road map to anticancer drug development from discovery to NDA submission
  • Discussion of molecular targets and preclinical screening
  • Development and validation of bioanalytical methods
  • Chapters on clinical trial design and phase 0, I, II, III clinical trials
  • Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents
  • Review of the drug development process from both laboratory and clinical perspectives
  • New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
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Conservation: Protecting Our Plant Resources (Green Technology)
Conservation: Protecting Our Plant Resources (Green Technology)

Conservation refers to the careful and controlled use of natural resources for the purpose of extending the time they are available as well as retaining biodiversity. Conservation does not prevent the loss of plants, trees, land, water, or habitat; it simply slows the rate of degradation of these things. This new book explores aspects of...

Math Puzzles and Games, Grades 6-8: Over 300 Reproducible Puzzles that Teach Math and Problem Solving
Math Puzzles and Games, Grades 6-8: Over 300 Reproducible Puzzles that Teach Math and Problem Solving
In the 1950s we punished misbehaving students in middle school or junior high school by making them stay after school to do 100 multiplication or long-division math problems. Mathematics was taught in a highly ordered and mechanically repetitive manner with the objective being to master basic arithmetic skills. A decade later New Math emerged as a...
Lua Quick Start Guide: The easiest way to learn Lua programming
Lua Quick Start Guide: The easiest way to learn Lua programming

The easiest way to learn Lua programming

Key Features

  • The easiest way to learn Lua coding
  • Use the Lua standard libraries and debug Lua code
  • Embed Lua as a scripting language using the Lua C API

Book Description

Lua is a...


Angular 6 for Enterprise-Ready Web Applications: Deliver production-ready and cloud-scale Angular web apps
Angular 6 for Enterprise-Ready Web Applications: Deliver production-ready and cloud-scale Angular web apps

A hands-on guide with a minimalist and flexible approach that enables quick learning and rapid delivery of cloud-ready enterprise applications with Angular 6

Key Features

  • Explore tools and techniques to push your web app to the next level
  • Master Angular app design and...
Vector Basic Training: A Systematic Creative Process for Building Precision Vector Artwork
Vector Basic Training: A Systematic Creative Process for Building Precision Vector Artwork

The one question I get asked most by other creatives is, “How do you get your vector artwork to look so nice?” When people ask me this, they’re not talking about any specific art project or illustration, but rather how I go about building my artwork in vector format so precisely.

Truth is that many...

Philosophy of Religion in the 21st Century (Claremont Studies in the Philosophy of Religion)
Philosophy of Religion in the 21st Century (Claremont Studies in the Philosophy of Religion)

"Scholars who are interested in getting up-to-date in contemporary philosophy of religion will find this book quite valuable."--Daniel A. Dombrowski, Religious Studies Review

The symposia and discussions presented here represent the proceedings of the 1999 annual philosophy of religion conference which took place at
...

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