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Hughes Syndrome: Antiphospholipid Syndrome

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The studies and discussions presented in the second edition of the Hughes Syndrome text had their beginning with a 1983 British Medical Journal publication entitled “Thrombosis, abortion, cerebral disease and the lupus anticoagulant.” In the mid-20th-century, it was recognized that some patients with systemic lupus erythematosus had biological false positive serological tests for syphilis, often coincident with the presence of an anticoagulant in plasma and the some of these patients (particularly ones with somewhat atypical of patterns of lupus) paradoxically manifested an increased incidence of procoagulant complications. Nothing much was made of these associations, however, until Graham Hughes, author of the above citation, applied his talents of astute bedside observation, knowledge of disease mechanisms, imagination, and a “bloodhound” instinct for following relevant clues. Graham and his colleagues early-on documented vasculopathy as basis for the diffuse (variable) pathology characteristic of the syndrome; evidence that procoagulant features were mediated by antiphospholipid autoantibodies (aPL) followed. Over the past two decades, investigators around the world have turned their attention to the study of the Hughes syndrome. (Contributors to this text include 83 clinicians and/or scientists from 13 countries in Europe, the Americas, Near East, and Asia. They represent more than a dozen clinical subspecialties and several basic science disciplines; professionals and students in these fields will need access to this book, whether in institutional libraries or personal collections – good news for the publisher.)
Introduction to JavaScript Object Notation: A To-the-Point Guide to JSON
Introduction to JavaScript Object Notation: A To-the-Point Guide to JSON

What is JavaScript Object Notation (JSON) and how can you put it to work? This concise guide helps busy IT professionals get up and running quickly with this popular data interchange format, and provides a deep understanding of how JSON works. Author Lindsay Bassett begins with an overview of JSON syntax, data types, formatting, and...

Pediatric Headaches in Clinical Practice
Pediatric Headaches in Clinical Practice

This book is a foundation for further study into childhood headache and serve as a quick, up-to-date reference for the recognition, diagnosis, basic understanding, evaluation and management of headache disorders in children and adolescents.

  • Covers primary headache disorders including migraine
  • Covers...
Microsoft Visual Basic: Developer's Workshop
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The authors of this guide present a smorgasbord of tips and techniques for Visual Basic developers. The first part details the new features of Visual Basic 6 and lays out conventions for clear and productive programming style. However, these important preliminary discussions are covered in only two quick chapters, and most of the book is...


Windows Server 2003: The Complete Reference
Windows Server 2003: The Complete Reference

Master new features for a more secure, easier to manage, network

The Most Comprehensive Windows Server 2003 Resource Available!

Examine the architecture and understand the features of Windows Server 2003 with help from this thorough resource. Written by respected author Kathy Ivens, Windows Server 2003: The Complete...

The Moscow Puzzles: 359 Mathematical Recreations
The Moscow Puzzles: 359 Mathematical Recreations
This book has been a classic in the former Soviet Union since it was first published in 1956, and it remains just as entertaining today. A master at making math fun for his high school students, Boris Kordemsky loaded this clever collection with a wide variety of math and logic related games and puzzles dealing with magic squares, tricky...
.NET Framework Standard Library Annotated Reference, Volume 1: Base Class Library and Extended Numerics Library, 1/e
.NET Framework Standard Library Annotated Reference, Volume 1: Base Class Library and Extended Numerics Library, 1/e

Edited by a Lead Program Manager on Microsoft's .NET Framework team, .NET Framework Standard Library Annotated Reference, Volume 1, is the definitive reference for the .NET Framework base class library. This book/CD set utilizes extensive annotations and code samples from the creators of the technology to...

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