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Infections and the Cardiovascular System: New Perspectives (Emerging Infectious Diseases of the 21st Century)

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Infectious agents have been recognized to involve the heart and vascular system for well over a century. Traditional concepts and teachings of their involvement in the pathogenesis of disease have been by a few established mechanisms. Bacterial and occasionally fungal microorganisms were known to invade and multiply on the endocardium of valves, vascular prostheses or shunts and aneurysm. Similarly viral, bacterial, mycobacterial, fungal, and parasitic pathogens could cause disease by invasion of the pericardium and muscles of the heart. Pathogenesis of some diseases of the endocardium, myocardium, and pericardium could involve indirect mechanisms with molecular mimicry inducing injury through an autoimmune process, such as in rheumatic heart disease and post viral cardiomyopathy.

It was recognized by the mid-20th century that Treponema pallidum, the etiology of syphilis, could cause cardiovascular damage (aortitis and aortic aneurysm) by obliteration of the vasa vasorum supplying the root of the aorta by endarteritis obliterans, and by then the connection between streptococcal infection and rheumatic heart disease was clear.

Infectious agents have been recognized to involve the heart and vascular system for well over a century. Traditional concepts and teachings of their involvement in the pathogenesis of disease have been by a few established mechanisms. Since the last decade of the 20th century there has been renewed interest in the medical and public media on infectious diseases affecting the cardiovascular and cerebrovascular systems, through their relationship with the development of acceleration of atherosclerosis. This volume highlights and reviews new perspectives of infections on the cardiovascular system as never before. It is a truly valuable resource for scientists, researchers, residents, and fellows in the fields of infectious disease, cardiology, and microbiology.

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