Thoroughly revised and updated for its Sixth Edition, this classic work is the most comprehensive reference on diagnosis and treatment of neuro-ophthalmologic diseases. This edition has two new editors - Valerie Biousse, MD and John B. Kerrison, MD and has been streamlined from five volumes into three tightly edited volumes with a sharper...

Dr. Burke Cunha, one of the foremost experts in the field of infectious disease, has put together an outstanding comprehensive issue with an exceptional team of authors that covers the most important updates in antimicrobial therapy. Treatment of helicobacter pylori, clostridium difficile, macrolide resistant S. pneumonia, and serious...

The October 2007 edition of Clinics in Sports Medicine will focus on anterior cruciate ligament (ACL) reconstruction graft selection and graft fixation. The twelve chapters will be written by some of the world's foremost experts on ACL reconstruction. The topics will specifically include the use of: ipsilateral and contralateral patella...

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division...

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and...

A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional...

A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated...