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Insulin Resistance: Insulin Action and its Disturbances in Disease
Insulin Resistance: Insulin Action and its Disturbances in Disease
Hormone resistance syndromes are typically thought of as rare, usually genetic, disorders with a severe but relatively stereotyped clinical and biochemical profile. While there are syndromes of severe insulin resistance that conform to this description, defective insulin action is of much more pervasive biomedical importance....
Primary Intraocular Lymphoma
Primary Intraocular Lymphoma
In medicine and science, two inseparable sisters, a modern renaissance has occurred in which the pursuit of knowledge has provided the world with fascinating discoveries and answers to age-old questions. Perhaps one of the most shining and striking moments in this modern renaissance was the elucidation of the human genome. From...
Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications, and Therapeutic Implications
Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications, and Therapeutic Implications

In the post-genomic era we have, at our fingertips, an incredible array of genomic sequences from a multitude of complex organisms. There remains, however, the critical need to understand the precise roles individual genes play in complex biological milieu. Synthetic nucleic acids are at the cutting-edge of molecular strategies that target...

MRI of the Liver: Imaging Techniques, Contrast Enhancement, Differential Diagnosis
MRI of the Liver: Imaging Techniques, Contrast Enhancement, Differential Diagnosis
The practicing radiologist is continually challenged to update his/her competencies so as to deliver state-of-the-art radiological care. Nowhere is this truer than in the rapidly evolving world of magnetic resonance imaging, where innovations in both technology and diagnostic pharmaceuticals have dramatically altered the landscape...
Cured of Cancer: From childhood to adulthood quality of Survival (Uva Proefschriften)
Cured of Cancer: From childhood to adulthood quality of Survival (Uva Proefschriften)
Over the past decades, paediatric oncologists, paediatric oncology nurses and other health-care professionals caring for children with cancer have witnessed profound changes in the nature of their practice. Whereas care of the child with cancer was 30 or 35 years ago a matter of controlling pain and keeping the child as...
Mitochondrial Biology: New Perspectives (Novartis Foundation Symposia)
Mitochondrial Biology: New Perspectives (Novartis Foundation Symposia)

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of...

Quantitative MRI of the Brain: Measuring Changes Caused by Disease
Quantitative MRI of the Brain: Measuring Changes Caused by Disease

This book was conceived one balmy March evening on the banks of the river Brisbane, in Queensland, Australia, where I had just arrived for a sabbatical, and it became clear that the traditions of measurement science and MRI should meet. The notion of a guide, a cook-book, for quantitative MRI (qMR) techniques took seed, and attained its own...

Immunology and Immunopathogenesis of Malaria (Current Topics in Microbiology and Immunology)
Immunology and Immunopathogenesis of Malaria (Current Topics in Microbiology and Immunology)
Malaria is still a major global health problem, killing more than one million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on sub-Saharan Africa, where over 90% of these deaths are...
Congestive Heart Failure
Congestive Heart Failure
Having first decided to organize and edit a book on heart failure in 1992 (with a 1994 publication date), we have been astounded at the changes in the field over a relatively brief 14-year period. It is with some amusement that we now look back at our first edition and note a combined chapter of beta agonists and...
A Personal History of Nuclear Medicine
A Personal History of Nuclear Medicine

A Personal History of Nuclear Medicine is an account of how nuclear medicine developed, and its basic philosophy in the past, present and future. The book outlines the history of the development of nuclear medicine as experienced by the author and describes the hurdles that nuclear medicine has had to face, in view of the perception of...

Pocket Guide to Critical Care Pharmacotherapy
Pocket Guide to Critical Care Pharmacotherapy
Critical care medicine is a cutting-edge medical field that is highly evidence-based. Studies are continuously published that alter the approach to patient care. As a critical care clinician, I am aware of the tremendous commitment required to provide optimal evidence-based care. Pocket Guide to Critical Care...
Principles and Practice of Pediatric Surgery
Principles and Practice of Pediatric Surgery
In the preface to the text that preceded this edition, we predicted that the pace of change in the clinical practice of pediatric surgery, and in our understanding of the scientific principles that are the basis for that practice, would soon render the text obsolete. That expectation was more predictable than prescient,...
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