Adaptive design has become an important tool in modern pharmaceutical research and development. Compared to a classic trial design with static features, an adaptive design allows for the modification of the characteristics of ongoing trials based on cumulative information. Adaptive designs increase the probability of success, reduce costs...
Get an easy introduction to reactive streams in Java to handle concurrency, data streams, and the propagation of change in today's applications. This compact book includes in-depth introductions to RxJava, Akka Streams, and Reactor, and integrates the latest related features from Java 9 and 11, as well as reactive streams...
Explore the features of this innovative open source language in depth, from working with the type system through object-orientation to understanding the runtime and the TypeScript compiler. This fully revised and updated second edition of Steve Fenton’s popular book covers everything you need to discover this fascinating...
How to reach your fitness goals, prevent pain and injury, and achieve optimal performance in work, sports, and life.
Pain is a byproduct of our busy, active lives, but it doesn’t have to be a constant and hindering presence. Whether your daily activity consists of caring for children, or training for marathons, Dr....
This book provides a concise introduction to the behavior of mechanical structures and testing their stochastic stability under the influence of noise. It explains the physical effects of noise and in particular the concept of Gaussian white noise. In closing, the book explains how to model the effects of noise on mechanical...
Provides important information from anatomy to pathophysiology and covers most neurological disorders that involve venous circulation. Venous circulation has not been extensively studied and we know relatively little about cerebral venous circulation. Venous circulation contributes to half of the brain circulation and about 70% of...
Thanks to recent advances in sensors, communication and satellite technology, data storage, processing and networking capabilities, satellite image acquisition and mining are now on the rise. In turn, satellite images play a vital role in providing essential geographical information. Highly accurate automatic classification and decision...
