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In the last decade, the delineation of the human genome and the development of high throughput genomics and proteomics have transformed the practice of Pediatrics. The study of normal childhood growth and development, and pediatric diseases now focuses on the delineation of normal and abnormal gene expression, resultant cellular and organ responses, and the modification of such interactions by an increasing number of environmental factors. This is the first of two issues of the Pediatric Clinics of North America will provide an overview of the rapidly developing field of Pediatric Translational Medicine. New knowledge of basic molecular and developmental physiology and pathophysiology is rapidly being "translated" into new diagnostics and therapeutics for the practicing pediatrician. Rapid molecular diagnostics based on the identification of new disease genes, recognition of unique disease phenotypes at the cellular level, and the development of new therapeutic approaches based on pharmacogenomic profiling suggest that "individualized medicine" will soon be a possibility for every child. Combined with similar advances in epidemiology, bioinformatics, and population-based studies, Pediatric Translational Medicine will rapidly move from the laboratory bench to the patient bedside. These issues of the PCNA will be of value to all members of the pediatric health care delivery team, which now includes basic and clinical investigators. Further, it will provide students at all levels with a sense of the excitement which awaits their future development as tomorrow's Physician-Scientists. |
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 Markov Models for Pattern Recognition: From Theory to Applications
The development of pattern recognition methods on the basis of so-called Markov
models is tightly coupled to the technological progress in the field of automatic
speech recognition. Today, however, Markov chain and hidden Markov models are
also applied in many other fields where the task is the modeling and analysis of
chronologically... |  | Frommer's Seattle 2010 (Frommer's Complete Guides)
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Completely updated every year, Frommer's Seattle features 16 pages of gorgeous color photos of the sights and experiences that await you.
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Our expert author has combed the city looking for the best hotels, restaurants, shops, and nightlife spots, and has created detailed walking tours to take you through some
... | | Stack Frames: A Look From Inside
Teaches you exactly how program memory content and organization is vital for computer security, especially Unix-like operating systems. You will learn how it is manipulated to take control of a computer system, as well as the countermeasures that system designers set up to avoid this. Neither a guide for hackers nor an all-out theory book,... |
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