This book addresses one of the most overlooked practical, methodological, and moral questions in the journey to secure and handle the massive amount of data being generated from smart devices interactions: the integration of Blockchain with 5G-enabled IoT. After an overview, this book discusses open issues and challenges, which may hinder the growth of Blockchain technology. Then, this book presents a variety of perspectives on the most pressing questions in the field, such as: how IoT can connect billions of objects together; how the access control mechanisms in 5G-enabled industrial environment works; how to address the real-time and quality-of-service requirements for industrial applications; and how to ensure scalability and computing efficiency. Also, it includes a detailed discussions on the complexity of adoption of Blockchain for 5G-Enabled IoT and presents comparative case studies with respect to various performance evaluation metrics such as scalability, data management, standardization, interoperability and regulations, accessibility, human-factors engineering and interfaces, reliability, heterogeneity, and QoS requirements. This book acts as a professional guide for the practitioners in information security and related topics.