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Genes, Development and Cancer: The Life and Work of Edward B. Lewis

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While Edward B. (‘Ed’) Lewis is famous for his contributions to genetics and developmental biology, few have read his research papers. One reason for this is availability, many having been published in obscure journals or as book chapters. A second is because his papers in those fields are very difficult to read. The difficulty derives from the fact that Lewis has published infrequently, thus many papers are condensed reviews of many years’ work presented largely in summary form rather than in detail. It is not unusual for the reader to have to infer the experimental methods, even the results, from a few sentences. Furthermore, he often presents his results in terms of abstract models; thus it can be difficult to separate the data from the models.

A major goal of this book is to make Lewis’ key papers accessible to researchers and students. The papers are grouped into several sections that reflect the changing focus of his research. Each section is preceded by commentary designed to place the papers in historical perspective, with respect to Lewis’ own ideas as well as to those of the larger scientific community. The commentaries attempt to highlight the key methods and results—as well as the significance—of each paper by explaining the science in terms that should be understandable to upper-level undergraduates, graduate students and professional researchers.
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