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Integrative Physiology in the Proteomics and Post-Genomics Age

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There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of function whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation.

It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism. However, despite the undeniable and spectacular successes of molecular biology, the lack of, and need for, an integrative perspective has become evident. This is particularly true in many clinical cases of gene and drug therapies that failed despite promising results from defined animal models.

Integrative Physiology in the Proteomics and Post-Genomics Age represents an attempt to highlight the major questions and accomplishments of modern physiological research. It re-addresses the fundamental questions of the classical concept, incorporating information gained from new molecular, genetic, and cellular technologies.
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