Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Targeting Treatment of Soft Tissue Sarcomas (Cancer Treatment and Research)

Buy
The last decade we have witnessed a major change in the development of new techniques and agents for the treatment of cancer in general, and for soft tissue sarcomas in particular. The important achievements of molecular biology research have changed the landscape markedly. Increasingly subtypes of soft tissue sarcomas are shown to be related to changes in cellular growth factors in the cell signaling pathways. This in theory enabled to development of agents with specific activity against these factors. The presence of the KIT receptor at the surface of the gastrointestinal stroma tumor cell, and the constitutive activation by mutations, has lead to the discovery of the specific KIT tyrosine kinase inhibitor Imatinib, an agent with impressive activity in this disease. Before the era of Imatinib, GIST was an untreatable disease once metastasized. Imatinib clearly is a breakthrough in the approach of soft tissue sarcomas, and will likely serve as a role model for the development of other agents acting towards other receptors. Likewise, soft tissue sarcomas with their specific molecular characteristics, will likely serve as role model diseases for targeted treatment approaches. Whether the future lies in drugs with selective inhibition of only one receptor and one pathway, or multiple receptors and multiple pathways is currently a matter of debate, and again soft tissue sarcomas serve as role model.

Fully in line with the more targeted approach in drug use, the changes in the field of radiation therapy and surgery basically also focus on a better targeting of the disease, albeit not based on the molecular characteristics yet.

The present volume of this series reflects all of the above mentioned changes. World wide renowned experts have been willing to contribute to this book, and we would like to thank all of them for their efforts. Hopefully this book will contribute to a better understanding of the changes in the field, and will serve our patients in helping getting a better future.
(HTML tags aren't allowed.)

Practical Security: Simple Practices for Defending Your Systems
Practical Security: Simple Practices for Defending Your Systems

Most security professionals don't have the words "security" or "hacker" in their job title. Instead, as a developer or admin you often have to fit in security alongside your official responsibilities - building and maintaining computer systems. Implement the basics of good security now, and...

Encyclopedia of Pharmaceutical Technology, Third Edition (Print) (Volume 2)
Encyclopedia of Pharmaceutical Technology, Third Edition (Print) (Volume 2)

Presenting authoritative and engaging articles on all aspects of drug development, dosage, manufacturing, and regulation, this Third Edition enables the pharmaceutical specialist and novice alike to keep abreast of developments in this rapidly evolving and highly competitive field. A dependable reference tool and constant companion for years...

iPhone User Interface Design Projects
iPhone User Interface Design Projects

With over 100,000 iPhone applications and 125,000 registered iPhone developers, is it still possible to create a top-selling app that stands apart from the six-figure crowd? Of course, but you’ll need more than a great idea and flawless code—an eye-catching and functional user interface design is essential. With this book,...


EMI Protection for Communication Systems
EMI Protection for Communication Systems

In recent years, the protection of communication services operating in the same of adjacent channels has become more and more challenging. Communication systems need to be protected from natural and man-made interference. This practical reference provides a through understanding of how to protect communication systems from intentional and...

Processing Big Data with Azure HDInsight: Building Real-World Big Data Systems on Azure HDInsight Using the Hadoop Ecosystem
Processing Big Data with Azure HDInsight: Building Real-World Big Data Systems on Azure HDInsight Using the Hadoop Ecosystem
Get a jump start on using Azure HDInsight and Hadoop Ecosystem components. As most Hadoop and Big Data projects are written in either Java, Scala, or Python, this book minimizes the effort to learn another language and is written from the perspective of a .NET developer. Hadoop components are covered, including Hive, Pig, HBase, Storm,...
Electricity And Magnetism (Physics in Our World)
Electricity And Magnetism (Physics in Our World)
THE NUCLEAR BOMBS that ended World War II in 1945 were a convincing and frightening demonstration of the power of physics. A product of some of the best scientific minds in  the world, the nuclear explosions devastated the Japanese cities of Hiroshima and Nagasaki, forcing Japan into an unconditional surrender. But even though the atomic bomb...
©2021 LearnIT (support@pdfchm.net) - Privacy Policy