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Volume 1, The Organic Chemistry of Drug Synthesis

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There exists today an abundance of excellent texts covering the various aspects of organic chemistry. The student of medicinal chemistry can choose among any of a number of first-rate expositions of that field. The reader who is primarily interested in the synthesis of some particular class of medicinal agents, however, will often find that he must consult either the original literature or some specialized review article. The same quandary faces the student who wishes to become acquainted with the biologic activity characteristic of some class of organic compounds. There thus seemed to be a place for a book that would cover specifically the chemical manipulations involved in the synthesis of medicinal agents. A book then was intended that would supplement both the available medicinal and organic chemistry texts.

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

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