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Cancer Drug Resistance (Cancer Drug Discovery and Development)
Cancer Drug Resistance (Cancer Drug Discovery and Development)

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport,...

Renal Cell Carcinoma: Molecular Biology, Immunology, and Clinical Management (Current Clinical Oncology)
Renal Cell Carcinoma: Molecular Biology, Immunology, and Clinical Management (Current Clinical Oncology)

Leading clinicians and researchers critically survey a decade of clinical, biological, and pathological knowledge, and show how it is best applied to the management of both localized and advanced renal cell carcinoma. Their discussions include the latest developments in molecular genetics and immune dysfunction, and fully treat the roles of...

Handbook of Copper Pharmacology and Toxicology
Handbook of Copper Pharmacology and Toxicology
Copper (Cu), an essential trace element, is required for the survival of organisms ranging from bacteria to mammals. Because Cu ions can adopt distinct redox states (oxidized Cu[II] or reduced Cu[I]), they play a pivotal role in cell physiology as catalytic cofactors in the redox chemistry of enzymes involved in a broad spectrum of...
Diabetes and Cardiovascular Disease (Contemporary Cardiology)
Diabetes and Cardiovascular Disease (Contemporary Cardiology)

This extensively updated and expanded second edition reflects new research, advances in clinical care, and the growing recognition that diabetes mellitus is a risk factor for cardiovascular disease. Written for the practicing clinician as a comprehensive review of diabetic vascular disease, the book both explains the basic pathophysiology of...

Pancreatic Cancer: Methods and Protocols (Methods in Molecular Medicine)
Pancreatic Cancer: Methods and Protocols (Methods in Molecular Medicine)
Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death in the United States. Annually approximately 30,000 Americans are diagnosed with the disease and most will die from it within five years. Pancreatic ductal adenocarcinoma is unique because of its late onset in age, high mortality, small tumor samples...
Forensic Pathology of Trauma (Forensic Science and Medicine)
Forensic Pathology of Trauma (Forensic Science and Medicine)
The practice of forensic pathology includes the collection and analysis of evidence in relation to a corpse in order to establish the cause of death. Knowledge of the cause of death contributes to the determination of the manner of death by medical examiners and coroners, who are occasionally assisted by law enforcement officers. In...
Integrative Physiology in the Proteomics and Post-Genomics Age
Integrative Physiology in the Proteomics and Post-Genomics Age
There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since...
Arthroscopic and Endoscopic Spinal Surgery: Text and Atlas
Arthroscopic and Endoscopic Spinal Surgery: Text and Atlas
The term “minimally invasive spinal surgery” was coined in early 1990 following publication of the first edition of this text entitled Arthroscopic Microdiscectomy: Minimal Intervention in Spinal Surgery, and subsequent establishment of the International Society for Minimal Intervention in Spinal Surgery (ISMISS) under...
Cytokines and Chemokines in Infectious Diseases Handbook (Infectious Disease)
Cytokines and Chemokines in Infectious Diseases Handbook (Infectious Disease)
Cytokines and chemokines are an important class of effector molecules that play a fundamental role in orchestrating the innate and acquired immune responses needed to eliminate or wall off invading pathogens. In vitro and in vivo studies have been instrumental in revealing the complexity of the cytokine network and the many facets of...
The Clinical Neurophysiology Primer
The Clinical Neurophysiology Primer
With the growth of combined clinical neurophysiology fellowship training programs and their corresponding “pan-physiology” board examinations, there has been an increased need for educational materials that span the range of clinical neurophysiology topics. The Clinical Neurophysiology Primer aims to meet this need by...
Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 1
Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 1
The aim of Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms is to present recent developments in cell survival and apoptotic pathways and their involvement in human diseases, such as cancers and neurodegenerative disorders. This requires an integration of knowledge from several fields of research, including...
Cardiac Repolarization (Contemporary Cardiology)
Cardiac Repolarization (Contemporary Cardiology)
There are a number of excellent books on molecular biology, single-channel electrophysiology, animal experimentation, and clinical electrophysiology. However, the past decade has seen an explosion of knowledge and radical changes in our understanding of ventricular repolarization as an integral part of the cardiac electrophysiologic...
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