The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and...
A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder...
A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by...
The original edition of this text, Clinical Evaluation of Medical Devices:
Principles and Case Studies, provided the first overview of key principles
and approaches to medical device clinical trials, illustrated with
a series of detailed, real-world case studies. The book is designed as a
resource for clinical professionals and...
This revised edition has been completely updated and expanded to address the latest developments and professional concerns in forensic medicine. There are new chapters on the medical aspects of police restraint and new material on the potential of police exposure to infection, the role of alcohol and drugs in vehicular accidents, and forensic...
During the past decade there have been enormous advances in the management of
patients with cardiac arrhythmias. Catheter ablation has become a first-line therapy for
a growing number of supraventricular tachyarrhythmias and idiopathic ventricular
tachycardia. Frequently performed on an outpatient basis, radiofrequency catheter...
Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and...
This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will...
A collection of new and essential molecular techniques for cardiovascular research. These readily reproducible methods range widely from producing congenic, consomic, transgenic, and knockout models of hypertension to the gene transfer of specific genetic material using nonviral (polymers, liposomes, and antisense agents) and adenoviral...
In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond...
Expert physicians and researchers in sports medicine comprehensively review what is known about how such activity effects the endocrine system and how in turn these evoked hormonal responses affect many other organs and systems of the body. Topics range from the various endocrine pathways that are altered by exercise, to the effect of...
Wolfgang Walther and Ulrike Stein survey the rapidly evolving field of cancer gene therapy and provide a broad array of leading-edge protocols for the delivery of therapeutic genes into tumors. Described in step-by-step fashion and enriched with each author's own practical tips, these readily reproducible methods are currently being...
