When I started HubSpot in June 2006 with my business partner, Dharmesh Shah, our experiences with marketing agencies led us to almost entirely avoid working with them. In fact, we designed our original business model around selling our marketing software directly to end customers, and developed an internal marketing team that would not be...

The number-one New York Times-bestselling novelist Patricia Cornwell is known the world over for her brilliant storytelling, the courage of her characters, and the state-of-the-art forensic methods they employ.

In this headline-making new work of nonfiction, Cornwell turns her trademark skills for meticulous research...

Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how...

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive...

Discontinuity in Nonlinear Physical Systems explores recent developments in experimental research in this broad field, organized in four distinct sections. Part I introduces the reader to the fractional dynamics and Lie group analysis for nonlinear partial differential equations. Part II covers chaos and complexity in nonlinear Hamiltonian...

Bioinformatics, which can be defined as the application of computer science and information technology to the field of biology and medicine, has been rapidly developing over the past few decades. It generates new knowledge as well as the computational tools to create that knowledge. Understanding the basic processes in living organisms is...

Chromatin is of central importance to gene regulation in eukaryotes.  Reflecting this singular role for chromatin, numerous approaches have evolved in the laboratory over the past three decades to study chromatin structure and its alterations. Methods of investigating chromatin remodeling, whether in changes in nucleosome structure or...

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical...

The book is dedicated to the method and application potential of micro segmented flow. The recent state of development of this powerful technique is presented in 12 chapters by leading researchers from different countries. In the first section, the principles of generation and manipulation of micro-fluidic segments are explained. In the...

Covering fractional order theory, simulation and experiments, this book explains how fractional order modelling and fractional order controller design compares favourably with traditional velocity and position control systems. The authors systematically compare the two approaches using applied fractional calculus. Stability theory in...