Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory...

Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...

Although depression is the most common presentation of bipolar disorder, correct diagnosis generally requires a history of mania and thus presents a formidable challenge. This book provides clinicians with the necessary guidance to distinguish this illness and pursue an appropriate therapeutic course. It brings together a team of clinical...

This book covers topics that range from fundamental studies of DNA replication, chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression. The basic and translational insights gained from Hormonal Control of Cell Cycle will be of interest to those studying the biology of endocrine tumors as...

Visual dysfunction is prevalent in Alzheimer’s disease and in related disorders such as posterior cortical atrophy and Down syndrome. The neuropathology of these disorders affects brain areas that process low-level vision as well as higher-order cognition and attention. This volume spans the range of topics on vision, from structure...

Privacy is one of the most urgent issues associated with information technology and digital media. This book claims that what people really care about when they complain and protest that privacy has been violated is not the act of sharing information itself―most people understand that this is crucial to social life ―but the...

Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate...

A Concise Introduction to Matlab is a simple, concise book designed to cover all the major capabilities of MATLAB that are useful for beginning students. Thorough coverage of Function handles, Anonymous functions, and Subfunctions. In addition, key applications including plotting, programming, statistics and model building are...

This volume presents the latest global knowledge of thyroid disorders in infancy, childhood, and adolescence and represents experience and views from a panel of the world’s most renowned authorities on thyroid pathophysiology and clinical entities in the pediatric population. Both basic science and clinical aspects of thyroid disease...

This book, written by international experts, is a detailed guide to the Eustachian tube, with emphasis on those aspects of most relevance to the practitioner. The opening chapters document the clinical anatomy and provide essential information on physiology, with explanation of the new model of tubal mechanics. Diagnosis and therapy for the...