There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental...

Crystal engineers aim to control the way molecules aggregate in the crystalline phase and are therefore concerned with crystal structure prediction, polymorphism, and discovering the relative importance of different types of intermolecular forces and their influence on molecular structure. In order to design crystal structures, knowledge of...

The model-based investigation of motions of anthropomorphic systems is an important interdisciplinary research topic involving specialists from many fields such as Robotics, Biomechanics, Physiology, Orthopedics, Psychology, Neurosciences, Sports, Computer Graphics and Applied Mathematics. This book presents a study of basic locomotion forms...

Age-Period-Cohort Analysis: New Models, Methods, and Empirical Applications is based on a decade of the authors’ collaborative work in age-period-cohort (APC) analysis. Within a single, consistent HAPC-GLMM statistical modeling framework, the authors synthesize APC models and methods for three research designs:...

Over the last decade the increasing phenomenon of suicide terrorism has raised questions about how it might be rational for individuals to engage in such acts. This book examines a range of different forms of political self-sacrifice, including hunger strikes, self-burning and non-violent martyrdom, all of which have taken place in resistance...

Variceal Hemorrhage provides an update of the evidence concerning several aspects of variceal hemorrhage. The book features new information on natural history, diagnosis of esophageal varices, assessment of the risk of bleeding and identification of high risk groups and patients who may benefit or be harmed from different treatments....

Now the publishers of the most accurate reference for FDA-approved drug information brings you the complete, authoritative...

Blood Cells has been written with both the practising haematologist and the trainee in mind. It aims to provide a guide for use in the diagnostic haematology laboratory, covering methods of collection of blood specimens, blood film preparation and staining, the principles of manual and automated blood counts and the assessment of the...

The first book of its kind, Power Converters and AC Electrical Drives with Linear Neural Networks systematically explores the application of neural networks in the field of power electronics, with particular emphasis on the sensorless control of AC drives. It presents the classical theory based on space-vectors in...

Due to its high sensitivity and selectivity, liquid chromatography–mass spectrometry (LC–MS) is a powerful technique. It is used for various applications, often involving the detection and identification of chemicals in a complex mixture. Ultra Performance Liquid Chromatography Mass Spectrometry: Evaluation and Applications in...

Following an introduction to the role of PK and PD in the development of biotech...