Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological...

While most books on chart patterns, or pattern recognition, offer detailed discussion and analysis of one type of pattern, the fact is that a single pattern may not be very helpful for trading, since it often does not give a...

Middleware is...

A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire...

No matter how professional your IT organization, if you can't resolve problems quickly and effectively, you'll lose your stakeholders' confidence—and fail. Nowadays, help desk s aren't enough: companies want true service centers capable of delivering complex,...

There’s a good reason project risk management is one of the most vital of the nine content areas of the Project Management Body of Knowledge®. Important projects tend to be time constrained, pose huge technical challenges, and suffer from a lack of adequate resources. It’s no wonder that project managers are increasingly focusing...