Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models...

Hepatitis delta virus (HDV), which causes severe acute and chronic liver disease, was discovered nearly 30 years ago following the detection of a novel antigen-antibody system in hepatitis B virus carriers. HDV has continued to surprise and fascinate medical science ever since. This volume reviews recent developments in HDV research, from...

Filling a gap in the literature, this reference provides concise and practical guidelines for the diagnosis and management of sinusitis and furnishes an authoritative outline of our current understanding of the pathophysiology of this condition. Addressing a wide spectrum of issues related to the identification, epidemiology, and etiology of...

What do the following have in common: the promise of Botox as the key to everlasting youthful looks; E. coli O157 hamburger disease; a mysterious illness which killed 35 heroin users in 2000; and the assassination by poisoned umbrella-tip of a Bulgarian dissident in the 1970s? The answer is that all of these are caused by toxins, the powerful...

This reference supplies a comprehensive and current overview of every aspect of gastrointestinal microbiota. Expertly written chapters cover conventional and molecular techniques for the study of differing microbial populations, as well as the analysis of microbial activity and interaction with host bodies. Illustrative and up-to-date, this...

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious...

Linking fundamental microbiology concepts with the diagnosis and treatment of clinical infections, this one-of-a-kind, portable text delivers an essential...

Updating researchers on phenomenal progress in the field of molecular medicine the Encyclopedia of Medical Genomics and Proteomics offers trail-blazing studies and authoritative contributions from more than 400 specialists. An important and timely contribution to the biomedical community, the encyclopedia compiles...