Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called...

This definitive and comprehensive account of the human herpes viruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein Barr virus, cytomegalovirus and varicella-zoster virus. The diseases they cause are significant and often recurrent....

This book still remains the standard reference work on medical disorders in obstetric practice in the UK and UK-influenced areas such as the former...

The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all reaches of the human body. Today, clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary...

Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, this new edition succinctly summarizes in 450 pages the latest findings on hormone secretion and hormone action, as well as all the most recent insights into the physiology and pathophysiology of...

Pharmacotherapy Handbook provides the critical information you need to make drug therapy decisions for more than 140 diseases and...

This is the first comprehensive study guide covering all aspects of pediatric critical care medicine. It fills a void that exists in learning resources currently available to pediatric critical care practitioners. The major textbooks are excellent references, but do not allow concise reading on specific topics and are not intended to act as...

This interdisciplinary atlas is the fruit of cooperation among radiologists, orthopedic surgeons, traumatologists, and neurosurgeons. Clinically oriented, it covers all important diseases and injuries of the spine. Numerous illustrations are supplemented by concise descriptions of anatomy and pathophysiology, normal and abnormal MRI...

This new edition of Pediatric Gastrointestinal Disease is dedicated to the maintenance of a comprehensive approach to the practice of Pediatric Gastroenterology. Considered to be the definitive reference work, this fourth edition has been extensively reviewed. As a result, the size and content of various sections have been modified and new...

This authoritative work comprehensively examines all aspects of addictive disorders and their treatment. Leading researchers and practitioners identify best practices in assessment and diagnosis and provide tools for working with users of specific substances. Issues in working...

For more than a decade, Textbook of Physical Diagnosis has detailed how to derive the maximum diagnostic information from interviewing and examining patients. Now the text that has been labeled "the Gray's Anatomy of physical diagnosis" returns in a New Edition that continues to emphasize a "patient first" philosophy....