Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly...

The last decades have seen the rise of neuroscience to one of the most dynamic biomedical disciplines. With the development of powerful new techniques it has been possible to investigate specific physiological and pathological neural mechanisms and thus to elucidate the etiology of many neurodegenerative and neuromuscular diseases.This first...

The Secrets Series® is breaking new ground again. A two-color page layout, a portable size, and a list of the "Top 100 Secrets" in biostatistics and epidemiology help readers to better meet the challenges they face today. And, at no extra charge, purchasers also receive online access to the complete contents of the text via...

This book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the findings that have already emerged. Coverage extends to antipsychotics, antidepressants and mood stabilizing, cognitive-enhancing and anxiolytic drugs. The volume also examines...

Macrophages are an important part of the immune response and are characterized by their ability to phagocytose foreign matter. However the difficulties involved in macrophage isolation mean they are some of the body's least explored cells. Macrophage Methodology describes how to isolate moderate to high yields of viable cells...

The hybrid/heterogeneous nature of future microprocessors and large high-performance computing systems will result in a reliance on two major types of components: multicore/manycore central processing units and special purpose hardware/massively parallel accelerators. While these technologies have numerous benefits, they also pose substantial...

The topic of the second volume of the series in "Essentials in Ophthalmology" is cataract and refractive surgery, a realm of ophthalmic care that has undergone revolutionary changes in the past 10 years. Worldwide, the removal of the opaque crystalline lens is the most frequently performed surgical intervention in the human body,...