“Read this book if you want to learn how to run efficient and effective...

Containing clear, practical advice,...

Reports on the latest advances in the field, for new and experienced scientists. Coverage includes the role of T-cells in multiple sclerosis (MS), T-cell autoimmunity and EAE in nonhuman primates, MBP-reactive T-cells in MS, and genetic engineering of brain-specific T-cells for treatment of diseases in the central nervous system. Also...

The tumor necrosis factor/receptor [TNF/TNFR] superfamily consists of more than 20 transmembrane proteins with conserved N-terminal cysteine-rich domains [CRDs] in the extracellular ligand binding region. Members have wide tissue distribution and play important roles in biological processes such as lymphoid and neuronal development, innate...

Pheochromocytomas are rare but treacherous catecholamine-producing tumors, which if missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is, therefore, essential for effective treatment, usually by surgical resection. The manifestations are diverse and the tumor can mimic a variety of conditions, often...

Contemporary research on genetic control of disease-transmitting insects knows two kinds of scientists: those that work in the laboratory and those known as ‘field people’. Over the last decade, both groups seem to have developed differing research priorities, address fundamentally different aspects within the overall discipline...

From the emergence of clinical sleep medicine marked by the establishment of the harbinger Stanford Sleep Disorders Clinic in the mid 1970s, offspring sleep dis- ders clinics and centers have grown exponentially with the recognition of the unmet diagnostic and treatment needs of the reservoir of patients suffering from sy- toms of what are...

About half of the global burden of disease is due to chronic noncommunicable diseases such as obesity, metabolic disorders, cardiovascular diseases and cancer, which are all related to modifiable risk factors such as unbalanced diet and malnutrition as well as determinants such as behavior and lifestyle. Dietary patterns during the last few...

In recent years, progress in pain research has yielded substantial new insights, and this has profoundly altered our understanding of various orofacial pain conditions. Written by renowned international researchers and clinicians, this state-of-the-art textbook presents recent advances in the understanding of orofacial pain and offers...

This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance...