Synthesizing decades of work, but up-to-date, this book focuses on organism-level responses to pollutants by marine animals, mainly crustaceans, molluscs, and fishes. Emphasizing effects on physiological processes (feeding/digestion, respiration, osmoregulation), life-cycle (reproduction [including endocrine disruption], embryo...

This publication is organized in an exceptional way: Each chapter introduces several completed clinical trials and provides the original conclusions and discussions of the results. The authors then contribute their own comments and interpretations of the findings, challenging the prevailing belief that serum cholesterol is a mediator of...

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive...

Nanotechnology is a new and emerging discipline that is multidisciplinary and interdisciplinary. The usage of nanosystems, nanomaterials, nano-devices, etc. permeates all aspects of society. Cancer targeting and curing nanosystems are being introduced into the biomedical and pharmaceutical industries; so are lightweight energy absorbing or...

While there are a plethora of practical texts relating to general gynecology, there are few specific to gynecological oncology. Taking a "cookbook" approach with clearly written and pictorial instructions, Atlas of Gynecologic Oncology: Investigation and Surgery describes and illustrates important procedures in the repertoire of a...

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for...

In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.

The metabolic network in cells promotes the generation of both energy and biomass needed for them to...

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor...