A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related...

Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human...

A comprehensive collection of cutting-edge methods to study and work with the vaccinia virus and other poxvirus gene transcriptions. These readily reproducible techniques can be used for the construction and characterization of recombinant viruses; for the study of poxvirus gene transcription and DNA replication; for the investigation of the...

A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological...

This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive...

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer. These comprehensive volumes integrate the...

- From the Foreword...

Yen Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging....

Using the available systematic reviews and Standard Options Recommendations (SORs) which are evidence-based treatment recommendations, Evidence-based Pediatric Oncology is a ground breaking text on the management of childhood cancers. Covering all tumour types occuring in children and young adults, it provides systematic reviews with...

This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan,...

The mechanism by which cigarette smoke causes or contributes to inflammatory diseases like chronic obstructive pulmonary disease, cardiovascular disease and cancer remains unclear. Recent developments in our knowledge of cellular signaling suggest that cigarette smoke may cause oxidative stress in cellular systems. The assessment,...