Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable,...
This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences resulting from the new European EMEA legislation, and how to develop appropriate information for...
Illuminating a hidden and fascinating chapter in the history of globalization, Paul Gootenberg chronicles the rise of one of the most spectacular and now illegal Latin American exports: cocaine.
Gootenberg traces cocaine's history from its origins as a medical commodity in the nineteenth century to its repression during...
Relied on for over 20 years by resident and practicing anesthesiologists and CRNAs, this best-selling pocket reference is now in its Seventh Edition. In easy-to-scan outline format, it provides current, comprehensive, concise, consistent, and clinically relevant guidelines for anesthesia procedures throughout the preoperative,...
This book focuses on the theoretical problems associated with molecular diversity as it is being applied in the pharmaceutical industry. Therefore, this book deals with algorithms that are involved in understanding chemical space and selection of diverse sets of structures. The algorithms also deal with the problem of focused diversity where...
In the flow of drugs to the United States from Latin America, women have always played key roles as bosses, business partners, money launderers, confidantes, and couriersâwork rarely acknowledged. Elaine Carey’s study of women in the drug trade offers a new understanding of this intriguing subject, from women drug smugglers in the...
There are many techniques of varying degrees of generality for the study
of mechanisms and that of free energy relationships is the most readily
applicable and general. Free energy relationships comprise the simplest
and easiest of techniques to use but the results are probably the trickiest
to interpret of all the mechanistic...
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...
Leo Kall is a zealous, middle-ranking scientist in the totalitarian World State who has just made a thrilling discovery: a new drug, Kallocain, that will force anyone who takes it to tell the truth. At last, criminality will be dragged out into the open and private thought can finally be outlawed. But can the World State be trusted...
This second revised and updated edition is a practical handbook on clinical trials in the growing field of osteoporosis. Topics covered include study design, technical issues, data collection, quality assurance, data analysis, and presentation. Clinical Trials in Osteoporosis takes the user through the process step-by-step from start to...
The main objective of this series is to offer a practice-oriented survey of techniques
currently used in Medicinal Chemistry. Following the volumes on Hansch analysis
and related approaches (Vol. 1) and multivariate analyses (Vol. 2), the present handbook
focuses on some new, emerging techniques in drug discovery; emphasis is...
The inspiring story of activist and poet Ian Manuel, who at the age of fourteen was sentenced to life in prison. He survived eighteen years in solitary confinement—through his own determination and dedication to art—until he was freed as part of an incredible crusade by the Equal Justice Initiative.
