Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl-...

This is the first uniform description of all key levels of communication in the organismic kingdoms of plants, fungi, animals and bacteria based on the most recent empirical data. Biocommunication occurs on three levels (A) intraorganismic, i.e. intra- and intercellular, (B) interorganismic, between the same or related species and (C)...

The rapid changes that have taken place globally on the economic, social and business fronts characterized the 20th century. The magnitude of these changes has formed an extremely complex and unpredictable decision-making framework, which is difficult to model through traditional approaches. The main purpose of this book is to present the...

In recent years the pace of research in prostate cancer has increased dramatically. Creative ideas in combination with new and emerging technologies have led to an explosion of discovery. These types of advances in prostate cancer research presage an era of new treatment strategies based on an understanding of the cellular and molecular...

Genetic Programming IV: Routine Human-Competitive Machine Intelligence presents the application of GP to a wide variety of problems involving automated synthesis of controllers, circuits, antennas, genetic networks, and metabolic pathways. The book describes fifteen instances where GP has created an entity that either...

This monograph describes the synthesis and use of biologically-inspired artificial hydrocarbon networks (AHNs) for approximation models associated with machine learning and a novel computational algorithm with which to exploit them. The reader is first introduced to various kinds of algorithms designed to deal with approximation problems and...

Preimplantation genetic diagnosis (PGD) is a key technique in modern reproductive medicine. Originally developed to help couples who were at risk of transmitting single-gene genetic abnormalities to their children, the development of the FISH technique broadened chromosome analysis to include detection of more complex inherited abnormalities....

The twentieth century began with the rediscovery of Mendel’s rules of inheritance and ended with the complete sequence of the human genome, one of the most monumental scientific accomplishments of all time. What lies in the future? What will the twenty-first century, the century of genomics, bring? Will geneticists a hundred years from...

Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new...

Approaches to building machines that can learn from experience abound - from connectionist learning algorithms and genetic algorithms to statistical mechanics and a learning system based on Piaget's theories of early childhood development. This monograph describes results derived from the mathematically oriented framework of computational...