Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth...

Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification...

Visual dysfunction is prevalent in Alzheimer’s disease and in related disorders such as posterior cortical atrophy and Down syndrome. The neuropathology of these disorders affects brain areas that process low-level vision as well as higher-order cognition and attention. This volume spans the range of topics on vision, from structure...

This book covers all the relevant aspects of communication in cancer care, such as communication in cancer prevention and genetic counseling, communication at different stages of disease and communication with the family and children. In addition, more general topics are discussed, such as the benefits and evidence of communication skills...

Reports on the latest advances in the field, for new and experienced scientists. Coverage includes the role of T-cells in multiple sclerosis (MS), T-cell autoimmunity and EAE in nonhuman primates, MBP-reactive T-cells in MS, and genetic engineering of brain-specific T-cells for treatment of diseases in the central nervous system. Also...

A Karger 'Publishing Highlights 1890–2015' title
Over the past years, research into the Prader-Willi syndrome (PWS) and its treatment options has progressed enormously and new insights have greatly improved the quality of life of those affected. For many years, Urs Eiholzer has been engaged in the care of...

While there are a plethora of practical texts relating to general gynecology, there are few specific to gynecological oncology. Taking a "cookbook" approach with clearly written and pictorial instructions, Atlas of Gynecologic Oncology: Investigation and Surgery describes and illustrates important procedures in the repertoire of a...

Practical and easy-to-read, this point-of-care reference provides a succinct,
clinical overview of eye anatomy, disease, and treatment. Unlike many ophthalmic
handbooks, OPHTHO NOTES classifies disease based upon etiology, rather than
presenting signs and symptoms. This classification helps to compartmentalize
...

A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection...

In the early 1990s, almost 200 yr after Edward Jenner demonstrated the effectiveness of the smallpox vaccine, a new paradigm for vaccination emerged. The conventional method of vaccination required delivery of whole pathogens or structural subunits, but in this new approach, DNA or genetic information was administered to elicit an...