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Toll-Like Receptors (TLRs) and Innate Immunity (Handbook of Experimental Pharmacology)
Toll-Like Receptors (TLRs) and Innate Immunity (Handbook of Experimental Pharmacology)
In the second half of the 20th century innate immune responses of cellular or humoral type were treated like stepchildren by many immunologists: that is, somewhat neglected. This disregard turned into an exciting research field over the past several years and led to the identification of receptor families involved in the recognition...
Principles of Renal Physiology
Principles of Renal Physiology

A good knowledge of renal physiology is essential to the understanding of many disease states. The purpose of the book is to set out the principles of renal physiology and normal renal function. Now in its 30th year of continuous publication, this new edition offers a logical progression through renal physiology and pathophysiology. In...

Insulin & Related Proteins _ Structure to Function and Pharmacology
Insulin & Related Proteins _ Structure to Function and Pharmacology

This book contains contributions presented at the last of the Alcuin Symposia, held in April 2000, as a Festschrift to honour Prof. Axel Wollmer on the occasion of his retirement from the Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen. The Alcuin Symposia were initially held alternatively in York and Aachen, in recent years...

Chirality in Drug Research (Methods and Principles in Medicinal Chemistry)
Chirality in Drug Research (Methods and Principles in Medicinal Chemistry)

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals.

The two editors from academia and a major pharmaceutical company have assembled an experienced,...

Special Issue on Emerging Bacterial Toxins (Reviews of Physiology, Biochemistry and Pharmacology)
Special Issue on Emerging Bacterial Toxins (Reviews of Physiology, Biochemistry and Pharmacology)
Many bacterial ADP-ribosyltransferases are potent bacterial protein toxins and important virulence factors. After cellular uptake caused by highly efficient cell entry mechanisms, they modify eukaryotic target proteins with great specificity and often grossly affect biological functions of their targets. These properties of the...
Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects, Volume 54 (Current Topics in Membranes)
Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects, Volume 54 (Current Topics in Membranes)

Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called...

Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications (Methods in Pharmacology and Toxicology)
Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications (Methods in Pharmacology and Toxicology)
Over the past three decades the field of immunotoxicology, the study of the effects of exposure to drugs, chemicals, or physical/environmental agents on the structure and function of the immune system has benefited from an increasingly detailed understanding of the cellular and molecular basis of innate and acquired immunity....
Core Topics in Neuroanaesthesia and Neurointensive Care
Core Topics in Neuroanaesthesia and Neurointensive Care

Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which...

Vitamin K in Health and Disease (Oxidative Stress and Disease)
Vitamin K in Health and Disease (Oxidative Stress and Disease)

Vitamin K: Past, Present, Future

Essential for normal blood coagulation, possible roles in bone, vascular, and tumor metabolism, and a nutrient critical to the health of the newborn infant -- these are just some of the many health-promoting aspects of Vitamin K. Vitamin K in Health and...

Drugs Compromising Male Sexual Health
Drugs Compromising Male Sexual Health

This concise drug guide lists 500 substances, such as pharmaceutical drugs, lifestyle drugs, and environmental toxicants, which show documented untoward effects on the male sexual organs and their functions. All substances are listed in user-friendly alphabetical order with a uniform structure throughout the book. Each listing includes...

Depression, the Mood Disease (A Johns Hopkins Press Health Book)
Depression, the Mood Disease (A Johns Hopkins Press Health Book)

Depression is a mood disorder that affects one in ten Americans in any given year. At one time too stigmatized to be mentioned in polite conversation, depression is now discussed frankly in the media, and advertisements for drug therapy appear everywhere. The third edition of this widely acclaimed book reflects changes in how mood disorders...

Reviews of Physiology, Biochemistry and Pharmacology 157
Reviews of Physiology, Biochemistry and Pharmacology 157

E. Bettiol, S. Clement, K.H. Krause, and M.E. Jaconi: Embryonic and Adult Stem-Cell Derived Cardiomyocytes: Lessons from in vitro Models

N. Toda, K. Ayajiki: Phylogenesis of Constitutively Formed Nitric Oxide in Non-Mammals

S. Huang and J. Wikswo: Dimensions of Systems Biology

S. C. Sinha and S.R. Sprang:...

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