In recent years, the knowledge of how renal damage occurs in patients with plasma cell dyscrasias / myeloma has substantially increased. For the first time, this publication brings together issues relating to the diagnosis and pathogenesis of these disorders, as well as a summary of advances achieved in the treatment and management of...
The last decade we have witnessed a major change in the
development of new techniques and agents for the treatment of cancer in
general, and for soft tissue sarcomas in particular. The important
achievements of molecular biology research have changed the landscape
markedly. Increasingly subtypes of soft tissue sarcomas are shown...
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that...
Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular...
This volume presents the latest global knowledge of thyroid disorders in infancy, childhood, and adolescence and represents experience and views from a panel of the world’s most renowned authorities on thyroid pathophysiology and clinical entities in the pediatric population. Both basic science and clinical aspects of thyroid disease...
This volume reviews the unique and common features of rhabdoviruses, which have a very wide host range and are associated with human diseases and also infect domestic livestock and agricultural plants, causing enormous economic loss.
Through the combination of the latest imaging modalities and microdevice delivery, interventional neuroradiologic techniques are currently revolutionizing the therapy for many of the most common neurological and neurosurgical disorders. Crossing the boundaries of classically delineated medical and surgical specialties including neurosurgery,...
Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human...
This comprehensive, richly illustrated textbook provides a systematic approach to frequent otological operations. Procedures in surgery of the ear canal, acute and chronic middle ear diseases, otosclerosis, cochlear implantation and vertigo are visualized step-by-step to acquaint the beginner with proven surgical repertoires. The book is...
A summary of the most recent and effective techniques for treating difficult functional problems and painful situations using minimally invasive spinal surgery techniques. Including an up-to-date review of the physiopathology of the diseases.
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As...
In the second half of the 20th century innate immune responses of cellular or humoral
type were treated like stepchildren by many immunologists: that is, somewhat
neglected. This disregard turned into an exciting research field over the past several
years and led to the identification of receptor families involved in the recognition...
