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Toxicology of the Pancreas (Target Organ Toxicology Series)
Toxicology of the Pancreas (Target Organ Toxicology Series)
The increased incidence of pancreatic cancer in the Western world and its grave prognosis has resulted in an urgency for research in this area. Until now the available data on toxicology of the pancreas has been few and fragmentary, scattered throughout the literature. A benchmark volume, Toxicology of the Pancreas pulls together information in...
Biosimulation in Drug Development
Biosimulation in Drug Development
Drug development is far from a straightforward endeavor. It starts with the identification of a pharmaceutically promising substance, the potential of which is further investigated in near-exhausting physiological analyses (Chapter 1). If it is found effective, this does not necessarily mean that we know all the molecular...
High Throughput Analysis for Early Drug Discovery
High Throughput Analysis for Early Drug Discovery

This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description...

Name Reactions in Heterocyclic Chemistry
Name Reactions in Heterocyclic Chemistry
Covers important name reactions relevant to heterocyclic chemistry

The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified...

North Korea: The Struggle Against American Power
North Korea: The Struggle Against American Power
George W. Bush's infamous remark about the 'Axis of Evil' brought North Korea dramatically back into the international spotlight. During the late 1990s relations between North Korea and the US and its allies were on the mend. However, the election of George W. Bush resulted in renewed crisis. The nuclear accord between the two...
Be Fast or Be Gone: Racing the Clock with Critical Chain Project Management
Be Fast or Be Gone: Racing the Clock with Critical Chain Project Management
Mike Knight, an executive in a semiconductor firm, learns that his eight-year-old son Tim has a rare form of brain cancer. Tim's best hope for long-term survival is a drug called Supragrel. Unfortunately, Supragrel is still in early clinical trials and may reach the market too late. Mike makes the agonizing decision to quit his job and go to...
Before Prozac: The Troubled History of Mood Disorders in Psychiatry
Before Prozac: The Troubled History of Mood Disorders in Psychiatry
Psychiatry today is a barren tundra, writes medical historian Edward Shorter, where drugs that don't work are used to treat diseases that don't exist. In this provocative volume, Shorter illuminates this dismal landscape, in a revealing account of why psychiatry is "losing ground" in the struggle to treat depression.

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Chembiomolecular Science: At the Frontier of Chemistry and Biology
Chembiomolecular Science: At the Frontier of Chemistry and Biology

At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug...

Polymers in Drug Delivery
Polymers in Drug Delivery

Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we’ve seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to...

Clinical Studies Management: A Practical Guide to Success
Clinical Studies Management: A Practical Guide to Success

What if you were suddenly in charge? After the initial excitement of a "battlefield promotion" wears off, you need to get in the trenches and get the job done. And if you are already in the trenches, you need quick access to information that will make your job easier. A comprehensive desk reference and guide, Clinical Studies...

Acres of Skin: Human Experiments at Holmesburg Prison
Acres of Skin: Human Experiments at Holmesburg Prison
In the first expose of unjust medical experimentation since David Rothman's Willowbrook's Wars, Allen M. Hornblum releases devastating stories from within the walls of Philadelphia's Holmesburg Prison. For more than two decades, from the mid-1950s through the mid-1970s, inmates were used, in exchange for a few dollars, as guinea pigs...
High-Throughput Image Reconstruction and Analysis (Bioinformatics & Biomedical Imaging)
High-Throughput Image Reconstruction and Analysis (Bioinformatics & Biomedical Imaging)

Progress in biology is dependent on the ability to observe, measure, and model the behavior of organisms at multiple levels of abstraction, from the microscopic to the macroscopic. There has been a tremendous growth recently in the techniques to probe the structure and workings of cellular and organ-level mechanisms. Significant advances have...

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