The wealth of insights into the brain’s functioning gained by neuroscience in recent years led to the development of new possibilities for intervening in the brain such as neurotransplantation, neural prostheses and brain stimulation techniques. Moreover, new and safer classes of psychopharmaceutical drugs lend themselves to...
This is a comprehensive handbook on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The book consists of a general part dealing with themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. The second part includes the...
With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation...
‘The conjugations may well be the most important drug biotransformation reactions.’ Thus reads the first sentence in Chapter 1 of this book; and indeed, this may be little realized, if one compares the overwhelming attention paid to cytochrome P-450-mediated biotransformation with what is published on the conjugations. Yet, oxidative...
âNeurocysticercosis (neural infection by larvae of Taenia solium) occurs when humans become intermediate hosts of the tapeworm Taenia solium after ingesting its eggs. The disease is now the most common helminthic infection of the nervous system in humans, and its prevalence has risen significantly even in countries where it was...
This wide-ranging book covers all the major religious traditions, while exploring monistic and theistic mysticism, and such key issues as altered states of consciousness, sex, and visionary experiences.
There is a widespread modem interest in religious affairs in the broadest sense, from Hare Krishna to the Jesus People and from...
This book presents basic and advanced principles underlying the multivalent
interactions that are prevalent in biological systems. To illustrate important or
complex concepts, the book provides up-to-date examples of synthetic multivalent
molecules, their design, and their biological benefits. Functional roles
displayed by such...
Diabetes is a disease with a fascinating history and one that has been growing dramatically with urbanization. According to the World Health Authority, it now affects 4.6% of adults over 20, reaching 30% in the over 35s in some populations. It is one of the most serious and widespread diseases today. But the general perception of diabetes is...
Scale-up is generally defined as the process of increasing batch size. Scale-up
of a process can also be viewed as a procedure for applying the same process
to different output volumes. There is a subtle difference between these two
definitions: batch size enlargement does not always translate into a size
increase of the...
Leading researchers, from the Novartis group that pioneered Gleevec/Glivec™ and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases,...
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the...
One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells...
