Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including...
Publius Syrus stated back in 42 B.C., “You cannot put the same shoe on every foot.” (Maxim 596) Though written long before the advent of forensic science, Syrus’ maxim summarizes the theme of Forensic Medicine of the Lower Extremity: Human Identification and Trauma Analysis of the Thigh, Leg, and Foot. Put simply, the lower...
With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation...
A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire...
Headache and Chronic Pain Syndromes provides a case-based approach to state-of-the-art evaluation and treatment of patients with common chronically painful conditions. Offering strategies for rapidly evaluating and treating pain complaints by body region, this innovative title also provides patient educational handouts that explain the...
These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough...
The brain in the second trimester, the subject of Volume
3, is nearing anatomical maturity throughout the brainstem. In contrast, the neurogenesis and neuronal migration are still in progress in the cerebral cortex and cerebellum. Consequently, the authors chose to focus on the migration, sojourning, and settling of the neuronal...
Is the risk of injury greater in some sport activities than in others? What types of injuries are most common? Are some children prone to sports injury? Are some physical, psychological, or sport-related factors associated with an increased risk of injury? Can injury be prevented and if so, how? Epidemiology of Pediatric Sport Injuries...
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!
This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory...
In the second half of the 20th century innate immune responses of cellular or humoral
type were treated like stepchildren by many immunologists: that is, somewhat
neglected. This disregard turned into an exciting research field over the past several
years and led to the identification of receptor families involved in the recognition...
The first book of its kind, Power Converters and AC Electrical Drives with Linear Neural Networks systematically explores the application of neural networks in the field of power electronics, with particular emphasis on the sensorless control of AC drives. It presents the classical theory based on space-vectors in...
