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 Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between... |  |  Pharmacogenetics of Psychotropic Drugs
This book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the findings that have already emerged. Coverage extends to antipsychotics, antidepressants and mood stabilizing, cognitive-enhancing and anxiolytic drugs. The volume also examines... |  |  The Investigation of Organic Reactions and Their Mechanisms
A range of alternative mechanisms can usually be postulated for most organic chemical reactions, and identification of the most likely requires detailed investigation. Investigation of Organic Reactions and their Mechanisms will serve as a guide for the trained chemist who needs to characterise an organic chemical reaction and investigate its... |
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 Insulin Resistance: Insulin Action and its Disturbances in Disease
Hormone resistance syndromes are typically thought of as rare, usually genetic,
disorders with a severe but relatively stereotyped clinical and biochemical profile.
While there are syndromes of severe insulin resistance that conform to
this description, defective insulin action is of much more pervasive biomedical
importance.... |  |  |  |  Biosimulation in Drug Development
Drug development is far from a straightforward endeavor. It starts with the identification
of a pharmaceutically promising substance, the potential of which is further
investigated in near-exhausting physiological analyses (Chapter 1). If it is found
effective, this does not necessarily mean that we know all the molecular... |
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